February 25, 2010

USA: Evidence of benefits of high BP drugs in diabetic eye disease

. ROCKVILLE, Maryland / Science Daily / February 25, 2010 Scientists in Massachusetts are reporting new evidence that certain high blood pressure drugs may be useful in preventing and treating diabetic retinopathy, the leading cause of vision loss in people with diabetes. The study, the largest to date on proteins in the retina, could lead to new ways to prevent or treat the sight-threatening disease, they say. The largest study to date of proteins in the retina, above, indicates that high blood pressure drugs may be useful in preventing diabetic eye disease. Credit: Wikimedia Commons, Danny Hope The findings are in the American Chemical Society's Journal of Proteome Research, a monthly publication. Edward Feener and colleagues point out that diabetic retinopathy is a common complication of diabetes, which affects millions of people worldwide. It involves damage to blood vessels in the retina, the light sensitive tissue in the back of the eye. Previous studies suggested that drugs used to treat high blood pressure, including ACE inhibitors and angiotensin receptor blockers (ARBs), may help prevent the condition. The scientists analyzed proteins from the retinas laboratory mice with normal blood pressure and diabetes and compared them to those of non-diabetic mice. They identified 65 abnormal proteins in the diabetic mice out of more than 1,700 proteins in the study. Treatment with the ARB medication, candesartan, prevented the abnormal changes in more than 70 percent of the proteins. [rc] Source: American Chemical Society Journal Reference: Gao et al. Angiotensin AT1 Receptor Antagonism Ameliorates Murine Retinal Proteome Changes Induced by Diabetes. Journal of Proteome Research, 2009; 8 (12): 5541 DOI: 10.1021/pr9006415 Copyright © 1995-2009 ScienceDaily LLC